Academic Events

PHARM-D MUHAMMAD ARSLAN KHAN PUBLISHES ON ANTIBIOTIC RESISTANCE

Abdulhamid Mpoza

When asked on what motivated him to write a scholarly article on Antibiotic Resistance, Muhammad Arslan Khan, a 10th semester Pharm-D student had this to say; “once you do a lot of laboratory based experiments and you find amazing results, it motivates you to share such with others.” “Moreover publishing benefits the community, the researcher, and the University at large.” He adds.

His abstract was first selected for an International Conference in Lithuania in 2015, but due to financial limitations, he failed to attend. His luck was in Malaysia where he linked up with other scientists to co-author an article on; “Stigmasterol: An adjuvant for beta lactam antibiotics against beta-lactamase positive clinical isolates.” Arslan’s scholarly piece is published by Steroids, an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids.

Arslan wants to pursue a Master of Science that will lead him to Doctor of Philosophy so that he settles as a renowned scientist. He considers the day when his paper was published as one of his happiest days in life. As a student, he has attended international research conferences in Malaysia and Turkey that have widened his exposure and research competence.

An abstract of Arslan’s co-authored paper;

“The emergence of beta lactamase producing bacterial strains eliminated the use of beta lactam antibiotics as chemotherapeutic alternative. Beta lactam antibiotics can be coupled with non-antibiotic adjuvants to combat these multidrug resistant strains. We study the synergistic antibiotic effect of stigmasterol as adjuvant of ampicillin against clinical isolates. Ampicillin was used in this study as a beta lactam antibiotic model. All test bacteria were beta lactamase producing clinical isolates. The combination showed significantly better antibiotic activity on all bacteria tested. The two test substances have synergistic antibiotic activity, and the effect was observed in both Gram positive and Gram negative bacteria. The synergistic antibiotic effect of stigmasterol and ampicillin was evident by the low fractional inhibitory concentration (FIC) index on Checkerboard Assay. The results suggest that the combination of ampicillin and stigmasterol acts additively in the treatment of infections caused by beta-lactamase producing pathogens. In bacterial growth reduction assay, ampicillin and stigmasterol alone exhibited very weak inhibitory effect on the bacterial growth, relative to ethanol control. Comparatively, combination of stigmasterol-ampicillin greatly reduced the colony counts at least by 98.7%. In conclusion, we found synergistic effects of stigmasterol and ampicillin against beta lactamase producing clinical isolates. This finding is important as it shows potential application of stigmasterol as an antibiotic adjuvant.”

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